تأثیر فعالیت ورزشی اجباری با شدت متوسط بر فراموشی ناشی از آلزایمر در رت های نر بالغ

نوع مقاله: مقاله پژوهشی

نویسندگان

1 استادیار، دانشگاه سمنان، ایران

2 دانشیار، دانشکدۀ تربیت بدنی و علوم ورزشی، دانشگاه تهران، ایران

3 استاد، انتسیتو پاستور تهران، ایران

چکیده

هدف این پژوهش بررسی فعالیت ورزشی اجباری با شدت متوسط بر فراموشی ناشی از آلزایمر در رت‌های نر بالغ بود. به این منظور  48 سر رت نر بالغ از نژاد آلبینو- ویستار به‌صورت تصادفی در شش گروه و هر گروه، 8 سر جایگزین شدند، شامل گروه‌های کنترل، دریافت‌کنندۀ دارونما (سالین)، دریافت‌کنندۀ دارو- ورزش، سالین- ورزش، ورزش و دریافت‌کنندۀ دارو. از داروی دیسیکلومین (mg/kg16) به‌منظور ایجاد فراموشی شبه‌آلزایمر و ورزش با شدت متوسط (60 دقیقه در روز×­30 روز)، استفاده شد. آموزش و آزمون حیوانات با استفاده از ماز آبی موریس انجام گرفت. یافته‌ها نشان داد که گروه دریافت‌کنندۀ دیسیکلومین نسبت به گروه ورزش، کنترل و سالین در مراحل اکتساب (044/0=P) و به‌خاطرآوری (031/0=P) تأخیر زمانی بیشتری در رسیدن به سکو داشت. اما بین گروه‌های ورزش، ورزش – سالین، نسبت به ورزش – دیسیکلومین اختلاف معناداری مشاهده نشد. همچنین نتایج نشان داد که اختلاف معناداری (تأخیر زمانی در رسیدن به سکو) بین گروه‌های دیسیکلومین– ورزش، سالین– ورزش نسبت به دیسیکلومین در مراحل اکتساب (005/0= P) و به‌خاطرآوری (002/0=­P)­، مشاهده شد. در نتیجه، نتایج این مطالعه نشان داد که دیسیکلومین موجب تخریب حافظه و یادگیری در مرحلۀ اکتساب و به‌خاطرآوری می‌شود و 30 جلسه دویدن با شدت متوسط (اجباری) می‌تواند از تخریب حافظه جلوگیری کند.

کلیدواژه‌ها


عنوان مقاله [English]

The Effect of Forced Physical Exercise with Moderate Intensity on Alzheimer-Induced Amnesia in Adult Male Rats

نویسندگان [English]

  • Mohammad Ali Salianeh 1
  • Rasoul Hemayattalab 2
  • Mahmoud Sheikh 2
  • Naser Naghdi 3
چکیده [English]

The aim of this study was to investigate the effect of forced physical exercise with moderate intensity on Alzheimer-induced amnesia in adult male rats. 48 male Wistar- Albino rats were randomly selected and assigned to 6 groups (n=8 per group): control, placebo (saline), drug-exercise, saline-exercise, exercise and exercise-drug. In this study, Dicyclomine (16 mg/kg) was used to induce Alzheimer-like amnesia and moderate exercise (60 minutes per day × 30 days). The rats were trained and tested using Morris water maze­. The findings showed that the group receiving Dicyclomine increased­ delay in reaching the platform­ in acquisition (P=0.044) and recall (P=0.031) compared with exercise, control and saline groups. But there were no significant differences between exercise and exercise-saline groups compared with exercise-Dicyclomine group. Also, a significant difference (delay in reaching the platform) was observed between Dicyclomine-exercise, saline-exercise compared with Dicyclomine in acquisition (P=0.005) and recall (P=0.002). In conclusion, this study showed that memory and learning in the acquisition and recall phases were destroyed by Dicyclomine and 30 sessions of moderate-intensity running (forced) could prevent memory corruption.

کلیدواژه‌ها [English]

  • Alzheimer’s disease
  • Cognitive Functions
  • forced exercise
  • Spatial Learning Rat
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